Testosterone undecanoate
The advantage of injecting testosterone undecanoate over other forms of injectable testosterone is that it requires fewer injections per year. This may help if you have problems with weekly injections. And since this is the only form of testosterone available in oral form, your doctor may prescribe Testosterone Undecanoate if you are a good candidate for oral testosterone treatment.
There are some differences in dosage and absorption between these different forms of testosterone. In short, everything is effective in raising serum testosterone levels to normal levels when needed (Petering, 2017). Be sure to take the dose prescribed by your doctor.
Testosterone undecanoate is a long-acting ester that maintains blood testosterone levels within the normal range without significant changes, and its half-life allows it to be administered every 3 months from onset. First occurrence within 6 weeks.
Testosterone is also known as an androgen or male sex hormone. But in reality, it is involved in many bodily functions in both men and women.
Testosterone undecanoate plays an important role in the development of male characteristics such as hair and muscle mass. It also plays an important role in bone strength and cholesterol processing. Testosterone levels can drop for a number of reasons, the most common of which is age. Other causes of low testosterone levels (called hypogonadism) include (Minnemann, 2008).
Benefits of Testosterone Undecanoate
Previously, testosterone was not suitable for oral administration. When this substance is ingested, the cells of this substance are damaged by the liver and the main male hormone in the body is not increased. Spread testosterone in ampoules between tablets, the most common of which is peanut butter. A pharmaceutical company called testosterone undecanoate does not break down the liver.
The testosterone system allows the active ingredients of the drug to penetrate the intestinal mucosa. The male hormone does not get into the bloodstream, but into the lymph. Not only does this allow for proper hydration, but it also has a non-toxic effect on the liver.
Damage to the pituitary gland (a gland in the brain that is responsible for signaling the testes to produce testosterone).
lack of some hormones
Chemotherapy or alcohol or heavy metal damage
Low testosterone levels can cause mood swings, decreased bone density, and sexual dysfunction. Clinical studies have shown that testosterone is safe and effective for treating hypogonadism symptoms in cis men (Mulhall, 2018).
Drug activity
Testosterone is converted to dihydrotestosterone in the undecanoate lymph. The benefits of the treatment are:
- Prohormone levels increase so estrogen is no longer secreted;
- There is no risk of water retention in the body;
- Gynecomastia is not a side effect;
- The female body does not reach the male.
Studies have shown that taking testosterone in the form of undecanoate does not impair the functioning of the nervous system, hypothalamus and pituitary gland.
Results of clinical research on drug efficacy
A recent 2014 study evaluated the efficacy of injectable testosterone undecanoate in 99 reported cases, 33 of which were included in the meta-analysis, with 11 reporting results from randomized controlled clinical trials [8-18].
The meta-analysis is based on the treatment outcomes of 3359 men who received testosterone undecanoate and 478 patients who received placebo. The average duration of androgen replacement therapy is 34.1 months.
The mean age of the patients in all studies was 56.8 years. The average testosterone level in the blood is 8.4 nmol / l and the body mass index (BMI) is 30.5 kg / m2.
Of the 33 clinical trials selected for the meta-analysis, six trials examined the effect of androgen replacement therapy in the general population (hypogonadal/eugonadal patients) and 27 trials examined the effect of the old hypogonadal (total testosterone ≤ 12 nmol). /L).
Male hypogonadism is a chronic pathological condition that has an extremely negative impact on almost all areas of a man’s life, often leading to significant physical, psychological and social consequences for his health. Therefore, the need for timely diagnosis and correction of male hypogonadism is clear.
The injectable form of Testosterone Undecanoate preparation has been used in modern European clinical practice for more than ten years. The results of the last meta-analysis from 2014 summarizing the experience with the use of testosterone undecanoate clearly show the high clinical efficacy of this form of testosterone in the treatment of various clinical manifestations of male hypogonadism.
With the correct selection of candidates for androgen replacement therapy, comprehensive examination of the patient, adequate evaluation of initial clinical and laboratory data and the presence of indications for androgen replacement therapy, as well as regular monitoring of the prostate status, the risk of occurrence is certain, even with regard to ineffectiveness.
This testosterone ester suppresses a follicular-sucking hormone (FSH) and the luteinization hormone (LH), which influences the signals required for eggs to produce spermatozoa, resulting in a decrease in the number of spermatozoa. The men usually do not feel the complete effect of treatment until after the first two or three months of the heading of the drug. The amount of spermatozoa remains low throughout the treatment period. The indicators are usually returned to the standard in two to six months after the treatment of treatment.
Chinese researchers first combined 200 mg (not mg) of the test orone of indekandoate with the oil of a tea tree and administers the formula intramuscularly. Men received periodic injections within 30 months. At the first tests from 80% to 90% of the men participating in the study, the amount of Spermatozoa was less than a million spermatozoa per milliliter (ML) ejaculate. The normal amount of Spermatozoa is on average about 20 million spermatozoa per ml. After three months of treatment, the male contraceptive was effective for 90-100%.